相关实验视频
Updated: Jul 31, 2025
08:02
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
5.5K
向PD-L2-RGMb可以克服与微生物相关的免疫疗法耐药性
Joon Seok Park1, Francesca S Gazzaniga1,2,3, Meng Wu1
1Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Nature
|May 3, 2023
概括
肠道微生物组可以通过降低PD-L2和RGMb来增强癌症免疫疗法. 这一发现为改善抗瘤免疫力提供了新的策略.
科学领域:
- 免疫学
- 微生物学
- 癌症学
背景情况:
- 在免疫检查点抑制剂 (ICI) 治疗期间,肠道微生物群影响抗瘤免疫力.
- 虽然受试者的便移植可以提高ICI的疗效,但机制尚不清楚.
- 识别特定的肠道细菌和通路对于优化癌症免疫治疗至关重要.
研究的目的:
- 阐明肠道细菌在ICI治疗中促进抗瘤免疫力的机制.
- 确定参与该过程的特定细菌物种.
- 探索克服PD-1通路抑制剂耐药性的新疗法.
主要方法:
- 研究了肠道微生物在调节PD-L2和排斥指导分子b (RGMb) 表达中的作用.
- 使用小鼠模型,包括无细菌和用抗生素治疗的小鼠,以及便微生物移植.
- 检查了与抗PD-1/PD-L1抗体结合在T细胞中阻断PD-L2-RGMb相互作用和条件RGMb缺失的影响.
主要成果:
- 表明肠道微生物组降低PD-L2和RGMb的表达,促进抗瘤免疫力.
- 显示阻断PD-L2-RGMb相互作用可以克服对PD-1通路抑制剂的耐药性.
- 证实了PD- L2- RGMb与PD- 1/ PD- L1抑制的联合阻断在耐药小鼠模型中增强了抗瘤反应.
结论:
- 肠道微生物群对PD- L2- RGMb通路的下调是促进对PD- 1检查点阻塞反应的关键机制.
- 针对PD- L2- RGMb途径是对目前PD- 1癌症免疫疗法无反应的患者的一个有希望的免疫策略.
更多相关视频
07:32A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
Published on: August 30, 2019
8.8K
07:55Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
894
相关概念视频
01:31Defense Against Bacterial Pathogens
1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
01:29Microorganisms in Medicine and Therapeutics
86
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
86
01:27Tumor Immunotherapy
587
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
587