皮层-皮层反会使视觉皮层中的活跃树突发生反应
Mehmet Fişek1, Dustin Herrmann2, Alexander Egea-Weiss2
1Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK. fisekm@gmail.com.
Nature
|May 3, 2023
概括
从较高视觉区域到主要视觉皮层的新皮层反是空间组织的. 这种反在空间偏移时促进知觉,在树突中非线性集成.
科学领域:
- 神经科学是一个神经科学.
- 视觉皮层研究 视觉皮层研究
- 皮层电路的皮层电路.
背景情况:
- 感官处理依赖于新皮质中的前和反通路.
- 反提供了上下文信息,有助于感知,但它的机制不太了解.
研究的目的:
- 研究从侧中视觉区域 (LM) 到主要视觉皮层 (V1) 的反影响的电路和细胞机制.
- 了解空间组织的反如何为视觉感知做出贡献.
主要方法:
- 在老鼠中进行远程全光学连接映射.
- 在V1金字塔神经元中进行双光子成像.
- 两光子光遗传学可以激活LM神经元.
主要成果:
- 从LM到V1的反是空间组织的:在视觉空间中对齐时抑制,在视觉空间中偏移时促进.
- 促进反是非线性地集成到V1金字塔神经元的顶端状树突中.
- 刺激向V1投射的LM神经元驱动特定于分支的树突性信号.
结论:
- 新皮层的反连接是空间组织的,并在上下文交互中发挥作用.
- 反的非线性树突集成支持预测和合作的感知功能.
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