编码保存的非尖端抗原的T细胞导向疫苗BNT162b4可以保护动物免受严重的SARS-CoV-2感染
Christina M Arieta1, Yushu Joy Xie1, Daniel A Rothenberg1
1BioNTech US, 40 Erie Street, Cambridge, MA 02139, USA.
Cell
|May 10, 2023
概括
一种新的疫苗成分BNT162b4增强了对SARS-CoV-2变种的T细胞免疫力. 结合现有疫苗,它减少了动物模型中的疾病严重性和病毒载荷,为未来的COVID-19保护提供了希望.
科学领域:
- 免疫学
- 疫苗学
- 病毒学
背景情况:
- 对于抗击SARS-CoV-2等β型冠状病毒感染,T细胞反应至关重要,与COVID-19的严重程度降低相关.
- SARS-CoV-2 变种对现有的疫苗诱导免疫力构成挑战.
- 针对保存的病毒表位可以扩大疫苗对进化变异的有效性.
研究的目的:
- 设计和评估针对保存的SARS-CoV-2表位的mRNA疫苗组件BNT162b4.
- 评估单独使用和与BNT162b2结合使用的BNT162b4的免疫性和保护性.
- 调查BNT162b4对SARS-CoV-2变种提供广泛保护的潜力.
主要方法:
- BNT162b4 设计用于编码SARS-CoV-2 核体,膜和ORF1ab 蛋白质的变异性保存部分.
- 通过测量动物模型中的多功能CD4+和CD8+T细胞反应来评估免疫性.
- 通过使用病毒变体,评估疾病严重程度和病毒标位,通过对子进行挑战研究来评估疗效.
主要成果:
- 在动物模型中,BNT162b4诱导多功能T细胞对多种表位的反应.
- 与BNT162b2的同时使用引起T细胞反应,同时保持突起特异性免疫力.
- 在感染SARS-CoV-2变种的仓鼠中,BNT162b4显示出对严重疾病的保护,并降低了病毒标位.
结论:
- 包括BNT162b4和BNT162b2在内的组合疫苗可以减少COVID-19的严重程度和持续时间,而不是当前和未来的变种.
- BNT162b4对增强T细胞介导的针对SARS-CoV-2的免疫力具有前景.
- 目前正在对BNT162b4与更新的双价疫苗进行临床评估.
更多相关视频
15:57Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
Published on: July 11, 2015
12.3K
08:13Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination
Published on: January 20, 2019
21.7K
相关概念视频
01:51Vaccinations
44.9K
Overview
44.9K
01:30Cancer Vaccines
449
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
449
01:27Cytotoxic T Cells-mediated Immune Response
1.0K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
1.0K
01:29Immune Response Against Viral Pathogens
839
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
839