宏观多细胞性的新演变
G Ozan Bozdag1, Seyed Alireza Zamani-Dahaj2,3, Thomas C Day3
1School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. ozan.bozdag@gmail.com.
Nature
|May 10, 2023
概括
雪花酵母通过生物物理适应在无氧条件下演变为宏观大小. 氧气的可用性对多细胞大小和复杂性的演变产生了重大影响.
科学领域:
- 进化生物学
- 生物物理
- 微生物学
背景情况:
- 多细胞系从简单的细胞群演变为达尔文的实体.
- 实现持续多细胞进化的生物物理机制尚不清楚.
研究的目的:
- 使用雪花酵母 (Saccharomyces cerevisiae) 进行长期实验,研究多细胞性的演变.
- 确定氧气可用性在多细胞大小和复杂性的演变中的作用.
主要方法:
- 在雪花酵母中进行了长期进化实验,
- 使用了三种代谢疗法:无氧,有氧和混合.
- 在600轮的选择中分析了大小,生物物理性和细胞形态的变化.
主要成果:
- 无氧雪花酵母进化到宏观大小 (毫米尺度),大小增加了2×10^4倍,度增加了10^4倍.
- 无氧条件下的宏观进化是由生物物理适应驱动的,包括细胞延长和分支纠.
- 在低氧条件下, 雪花酵母仍然微小,
结论:
- 氧气水平对于多细胞体型的演变至关重要.
- 生物物理适应,如细胞延长和纠,促进持续的多细胞进化.
- 这项研究提供了关于个性的进化过渡和克服早期多细胞生命中的生物物理限制的见解.
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