基于合成多的二次结构转换的蛋白质模拟纳米开关系统的合理构建
Chenglong Ge1, Junliang Zhu1, Huan Ye1
1Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.
Journal of the American Chemical Society
|May 11, 2023
概括
合成纳米开关通过使用多灵活性来控制功能来模仿天然蛋白质. 这些开关响应性酸酶激活,使得向癌症成像和治疗成为可能.
科学领域:
- 仿生材料科学
- 聚合物化学
- 纳米技术
背景情况:
- 自然的大分子表现出可调节的灵活性来控制功能,这种原则在合成系统中不太被探索.
- 开发模仿这种结构性质关系的合成类型对于先进的功能材料至关重要.
研究的目的:
- 通过聚连接器灵活性设计具有动态调节的生物功能的蛋白模拟纳米开关.
- 展示这些纳米开关在向癌症诊断和治疗方面的潜力.
主要方法:
- 纳米开关的构建包括一个金纳米粒子 (GNP) 核心,一个合成聚链接器和一个光学功能分子 (OFM).
- 在性酸酶 (ALP) 处理时利用聚联结器的形状转换 (卷轴到螺旋) 来改变GNP-OFM的近距离.
- 纳米开关对ALP诱导的形状变化的光学反应的描述.
主要成果:
- 纳米开关表现出休眠状态,随机卷曲的多因接近GNP而"关闭"OFM.
- 性酸酶 (ALP) 的激活诱导了线圈到螺旋转换,增加了分离并"打开"了OFM.
- 该系统允许选择性光成像或光动力疗法,响应瘤细胞过度产生的ALP.
结论:
- 控制合成聚合物的灵活性是操纵纳米开关光学活动的有效策略.
- 这种方法成功地模仿了天然蛋白质中发现的结构属性关系.
- 开发的纳米开关为有针对性的生物医学应用提供了一个有前途的平台,特别是在瘤学领域.
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