结核病患者吸烟药物使用与较高的细菌负担有关
B Myers1, T Carney2, J Rooney3
1Curtin enAble Institute, Faculty of Health Sciences, Curtin University, Perth, WA, Australia, Alcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Cape Town, South Africa, Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa.
概括
吸烟毒品的人 (PWSD) 在被诊断出结核病 (TB) 时表现出更高的细菌负担. 在PWSD中早期查结核病可以改善治疗联系并减少传播.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 成 药物 药物 药物 药物
背景情况:
- 非法吸毒对结核病 (TB) 进展的影响的研究是有限的.
- 吸烟非法药物的使用可能会加速结核病的进展或导致治疗延迟.
- 了解这种关联对于有效的结核病控制战略至关重要.
研究的目的:
- 调查吸烟药物使用与开始药物敏感结核病 (DS-TB) 治疗的患者的细菌负担之间的联系.
- 评估吸烟药物使用如何影响菌根菌荷载指标.
- 在脆弱人群中为结核病提供公共卫生干预信息.
主要方法:
- 分析了303名参与者在南非开始DS-TB治疗的数据.
- 吸烟药物使用的定义包括自我报告或核实使用甲基胺,甲基和/或大麻.
- 使用统计模型 (比例危险和后勤回归) 来检查与培养时间的阳性,唾液涂抹的阳性和肺腔位的关联,并根据相关的共变量进行调整.
主要成果:
- 超过一半的队列 (54.8%) 是吸毒者 (PWSD).
- PWSD表现出更快的培养阳性时间 (HR 1.48,P=0.008) 和更高的唾液涂抹阳性 (OR 2.28,P=0.011).
- 在吸烟药物使用和肺腔化之间没有发现显著的关联 (OR1.08,P=0.799).
结论:
- 吸烟毒品的人在结核病诊断时呈现出更高的真菌菌负担.
- 研究结果表明,针对PWSD的结核病查可以提高早期治疗的启动率.
- 早期干预可能会减少社区内结核病的传播.
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