对外体的全面审查:最近的进展和前景
Paras Agarwal1, Adiba Anees1, Raval Kavit Harsiddharay1,2
1Institute of Pharmaceutical Sciences, University of Lucknow, Lucknow, India.
Pharmaceutical nanotechnology
|May 26, 2023
概括
外体,细胞衍生的纳米纤维,显示承诺作为生物相容的药物输送系统,用于癌症和其他疾病. 它们向瘤和调节免疫反应的能力使它们在免疫疗法和治疗应用中具有价值.
科学领域:
- 生物技术是生物技术.
- 纳米医学是一种纳米医学.
- 免疫学 免疫学 免疫学
背景情况:
- 外体是细胞衍生的纳米纤维,参与正常和病理过程.
- 它们的独特特性,包括生物相容性和瘤向性,使它们成为药物输送的有希望的药物.
- 外体细胞因其免疫性和货物转移能力而越来越多地被认为是癌症免疫治疗中的潜力.
研究的目的:
- 提供对外体生物发生,隔离和药物输送应用的全面概述.
- 突出外体在癌症免疫疗法和其他治疗领域的潜力.
- 总结最近的临床进展和有关基于外体细胞的治疗方法的更新.
主要方法:
- 对外体研究现有文献的综述.
- 对药物输送和免疫治疗相关的外体特征的分析.
- 综合当前的临床试验数据和治疗应用.
主要成果:
- 外基因组表现出药物输送的有利特征,包括生物相容性,瘤热带性和稳定性.
- 外体可以被设计为有针对性的治疗有效载荷 (小分子,巨分子,核酸) 的传递.
- 外体具有免疫调节功能,使其对癌症免疫治疗具有吸引力.
结论:
- 外体体是先进药物输送系统的多功能平台.
- 它们在癌症免疫治疗中的应用是一个快速发展的领域,具有显著的临床潜力.
- 对外体生物发生,隔离和临床翻译的持续研究对于实现它们的全部治疗益处至关重要.
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