在社区样本中使用二和发生MCI和痴呆症的风险
Esther G Teverovsky1, Ariel Gildengers1, Xinhui Ran2
1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
International psychogeriatrics
|May 26, 2023
概括
在老年人中使用二 (BZD) 与患轻度认知障碍 (MCI) 的风险增加有关. 这种关联在认知正常的个体中观察到,并且不受APOE基因型的影响.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 青类药物 (BZDs) 经常被处方给老年人.
- 在这种人群中,长期使用BZD可能会对认知功能构成风险.
研究的目的:
- 调查使用二 (BZD) 与轻度认知障碍 (MCI) 或痴呆症的发展之间的关联.
- 检查在社区居住的认知正常的老年人中的这些风险.
主要方法:
- 一个基于人口的群体,由来自低社会经济地位社区的65岁以上的1959名成年人组成.
- 生存分析 (Cox模型) 评估了MCI或痴呆的时间,对共变量进行调整,包括APOE基因型相互作用.
- 测量包括BZD使用,认知状态 (CDR),焦虑,抑郁和睡眠困难.
主要成果:
- bensodiazepine (BZD) 使用与患轻度认知障碍 (MCI) 的风险更高显著相关.
- 在BZD使用和痴呆症的发展之间没有发现显著的关联.
- 观察到BZD使用与MCI风险之间的关联没有受到APOE基因型的改变.
结论:
- bensodiazepine (BZD) 的使用与在认知上正常的老年人中患轻度认知障碍 (MCI) 的风险增加有关.
- 在这个人口群体中,BZD使用代表了MCI的潜在可修改的风险因素.
- 进一步的研究是有必要的,以了解机制和临床影响.
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