长期使用Omalizumab治疗慢性疹的老年患者:这是一种安全的治疗方法吗?
Emilio José Narváez-Fernández1, Ana Entrala1,2, Ana Nin-Valencia1
1Department of Allergy, Hospital Universitario La Paz, Madrid, Spain.
International archives of allergy and immunology
|May 26, 2023
概括
奥马利祖马布 (OMA) 是老年患者慢性自发性疹 (CSU) 的安全有效治疗方法,与年轻人相比,不增加不良事件的风险. 这项研究提供了OMA的现实数据.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 生物药物,包括抗IgE单克隆抗体奥马利祖马布 (OMA),在治疗耐火性慢性自发性疹症 (CSU) 中至关重要.
- 由于OMA被排除在临床试验之外,对OMA在老年患者 (≥70岁) 的疗效和安全性数据有限.
- 老年患者面临着独特的挑战,包括并发症和多药,使CSU管理复杂化.
研究的目的:
- 评估奥马利祖马布 (OMA) 在老年患者 (≥70岁) 患有慢性自发性疹 (CSU) 和慢性诱导性疹 (CIndU) 的现实生活安全性.
- 在这个脆弱的老年人群中提供治疗疹的临床数据.
主要方法:
- 从2003年5月到2019年12月的CSU/CIndU患者病历的回顾性审查.
- 包括89名患者,分为两个年龄组:<70岁和≥70岁.
- 使用曼·惠特尼U和费舍尔测试的统计分析,p < 0.05被认为是显著的.
主要成果:
- 总体不良事件 (AE) 率为48%,主要是轻微的,年龄和AE发生之间没有显著的关联 (p=0.789).
- 没有报告严重的不良事件,如过敏反应.
- 慢性诱导性疹 (CIndU) 在老年人群中较少流行 (p=0.017);与一般人群相比,瘤发生频率没有显著差异.
结论:
- 奥马利祖马布 (OMA) 在CSU和CIndU的老年患者 (≥70岁) 中表现出良好的安全性,即使长期治疗.
- 这项研究表明,OMA对于老年疹患者来说是一个可行的治疗选择,尽管存在并发症.
- 建议对更大的队列进行进一步研究,以证实这些发现.
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