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相关概念视频

Development of Blood Vessels01:07

Development of Blood Vessels

663
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
663

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The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
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周产期间歇性缺氧会影响脑血管网络的发展吗?

Vanessa Coelho-Santos1,2,3,4, Anne-Jolene N Cruz1, Andy Y Shih1,2,5

  • 1Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, Washington, USA.

Developmental neuroscience
|May 26, 2023
PubMed
概括

发育过程中的慢性间歇性缺氧 (CIH) 可能会损害大脑血管的生长. 这可能导致脑血管功能持续问题,并导致神经发育障碍.

关键词:
大脑血管发育的发展.慢性间歇性缺氧 慢性间歇性缺氧神经发育 神经发育氧气 氧气 是一种周围产生的缺氧.

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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 生理学 生理学 生理学

背景情况:

  • 围产期缺氧,特别是慢性间歇性缺氧 (CIH),会影响早产婴儿.
  • CIH涉及重复的缺氧和再氧化,引发大脑炎症和氧化应激.
  • 脑血管发育在孕期和婴儿早期至关重要,与CIH风险相吻合.

研究的目的:

  • 探索CIH破坏正常脑血管发育的假设.
  • 调查CIH创造一个反循环,使代谢不足延续的潜力.
  • 了解CIH对大脑微血管结构和功能的长期影响.

主要方法:

  • 这篇小篇综述综合了关于CIH和脑血管发育的现有知识.
  • 它讨论了将CIH与血管生长受损联系起来的拟议机制.
  • 该审查审查了持久神经血管缺陷的潜力.

主要成果:

  • 据推测,CIH会破坏大脑微血管网络的正常发展.
  • 这种脱轨可能会导致一个积极的反循环,加剧代谢问题.
  • 血管结构和功能的异常被认为是CIH的后果.

结论:

  • 通过破坏发育,CIH可能会导致脑血管功能永久性缺陷.
  • 这些血管变化可能有助于神经发育障碍的病理生理学.
  • 需要进一步的研究来证实CIH对发展大脑血管系统的影响.