在炎症模型中对交感神经系统的慢性影响
Georg Pongratz1,2, Rainer H Straub3
1Department of Gastroenterology, Division of Rheumatology and Clinical Immunology, St. John of God Hospital, Regensburg, Germany.
Neuroimmunomodulation
|May 26, 2023
概括
交感神经系统 (SNS) 在慢性炎症中起着双重作用,最初促进它,后来成为抗炎作用. 这种神经免疫相互作用为炎症性疾病提供了潜在的治疗点.
科学领域:
- 神经免疫学 神经免疫学
- 自主神经系统的自主神经系统
- 炎症研究 炎症研究
背景情况:
- 免疫系统与调节系统相互作用,在挑战期间保持平衡.
- 神经内分泌免疫学研究强调了自主神经系统和免疫反应之间的相互作用.
- 交感神经系统 (SNS) 越来越多地被认为在慢性炎症疾病中的作用.
研究的目的:
- 审查有关SNS在慢性炎症疾病 (如大肠炎,多发性硬化症,全身性硬化症,红斑狼和关节炎) 中的作用的证据.
- 提出SNS对这些条件的贡献的理论框架,整合动物和人类数据.
- 在神经内分泌-免疫轴内识别潜在的治疗点.
主要方法:
- 对现有文献的审查,重点是动物模型和有关SNS和慢性炎症的人类数据.
- 对交感神经系统对炎症影响的双相性质的分析.
- 在炎症期间检查局部细胞内源性甲醇胺的产生.
- 在炎症状态下对神经神经系统激活与副交感神经系统活动的系统性分析.
主要成果:
- 脑神经系统表现出双相作用:在疾病发作之前具有促炎作用,在疾病发作后具有抗炎作用.
- 交感神经纤维在炎症部位丢失,导致局部catecholamine生产用于免疫调节.
- 在炎症期间观察到全身神经系统激活,与副交感神经系统活动形成鲜明对比.
- 慢性SNS过度活动与疾病后续有关.
结论:
- 了解SNS在慢性炎症中的复杂作用对于开发新疗法至关重要.
- 向上腺活性 (支持β-上腺,抑制α-上腺) 可能有利于诸如关节炎等炎症状况.
- 需要进一步进行受控的临床研究,以将神经内分泌免疫研究结果转化为患者的益处.
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