年轻人中风风险因素 (18-45岁):对来自32个国家的INTERSTROKE数据的病例对照分析
Maria Khan1, Mohammad Wasay2, Martin James O'Donnell3
1Rashid Hospital, Dubai Medical College for Girls, Dubai, United Arab Emirates.
Neuroepidemiology
|May 26, 2023
概括
传统的风险因素,如高血压,吸烟和过度饮酒,在45岁以下的人群中显著增加了中风风险. 高血压是所有年龄和中风类型的主要危险因素,强调了早期干预的必要性.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 传统的血管风险因素对45岁以下患者中风的作用尚不清楚.
- 这项研究旨在调查这一年轻人群中常见风险因素与中风发病率之间的关联.
研究的目的:
- 评估常见风险因素与45岁以下人中风的相关性.
- 确定年轻成年人中风预防的关键可修改的风险因素.
主要方法:
- 一项病例控制研究 (INTERSTROKE) 涉及32个国家1582例病例控制对 (2007-2015).
- 首次中风 (5天内) 的患者与没有中风病史的年龄和性别匹配的对照人群进行了比较.
- 几率比率 (ORs) 和人口归因风险 (PARs) 为45岁或更年轻的个体的各种风险因素计算.
主要成果:
- 高血压 (OR:5.41),狂饮 (OR:5.44),心脏病原因 (OR:8.42) 和吸烟 (OR:1.85) 是缺血性中风的重要危险因素.
- 高血压 (OR:9.08) 和狂饮 (OR:4.06) 是脑内出血的关键危险因素.
- 随着年龄的增长,患高血压的人群可归因的风险增加,在35-45岁年龄组达到50.7%.
结论:
- 传统的风险因素包括高血压,吸烟,暴饮暴食,肥胖,心脏问题,失脂症和心理社会压力是导致45岁以下人中风的重要因素.
- 高血压成为最关键的危险因素,不论年龄,地区或中风亚型.
- 早期识别和修改这些风险因素在年轻成年期对于预防中风至关重要.
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