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通过使用隔离的潜在益生菌和其表征来缓解牙损伤

Preeti Pallavi¹, Adyasa Barik¹, Naresh Sahoo²

¹Center for Biotechnology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.

Biotechnology and applied biochemistry

|May 26, 2023

概括

从酸奶中分离出来的Enterobacter cloacae PS-74有效地抑制了Streptococcus mutans,这是导致牙的关键原因. 这种有益的细菌减少了生物膜的形成,并为口腔治疗提供了潜力.

科学领域:

微生物学微生物学
益生菌益生菌是一种益生菌.
口腔健康口腔健康

背景情况:

突变性链球菌 (Streptococcus mutans) 是牙腐烂的主要病原体,负责生物膜形成和细菌粘附.
研究有益细菌抑制S. mutans对于开发新的口腔健康策略至关重要.

研究的目的:

从酸奶中分离出来的Enterobacter cloacae PS-74的特征,以其对抗Streptococcus mutans的益生菌特性.
评价E.cloacaePS-74无细胞超眠体 (CFS) 在抑制S.mutans生长和生物膜形成方面的疗效.

主要方法:

来自常规来源的有益细菌的隔离和表征.
确定抑制区,最小抑制度 (MIC) 和最小杀菌度 (MBC) 的 E. cloacae PS-74 CFS 对抗 S. mutans.
通过E.cloacae PS-74 CFS减少生物膜的量化.

主要成果:

肠杆菌cloacaePS-74显示显著抑制S. mutans,抑制区为29±1.7毫米.
对于CFSPS-74的MIC和MBC值分别为10μL和15μL,实现了S. mutans的99.9%的日志减少.
在MIC15时,CFS PS-74显著降低了S. mutans生物膜形成的84.91%,可能缓解牙损伤.

结论:

肠杆菌cloacaePS-74表现出强大的益生菌特性对流感菌突变菌,归因于有机酸的生产.
这项研究首次报告了E.cloacae PS-74的抗S.mutans活性,突出了其在口腔治疗中潜在的应用,以预防牙损伤.

关键词:

突变型链球菌 (Streptococcus mutans) 是一种突变型链球菌聚合方式聚合方式聚合方式抗生物膜是一种抗生物膜.这是一种抗原原的抗原原剂.没有细胞的超生体.牙腐烂是指牙的腐烂.益生菌是一种益生菌.

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