热邮件:免疫化学便隐性血液测试邮件返回期间的温度暴露
Geraldine Laven-Law1,2, Dawn Bastin1,2, Robert J L Fraser2,3
1Cancer Research, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia.
Clinical chemistry
|May 26, 2023
概括
使用稳定剂的现代便免疫化学测试 (FIT) 保持了对结直肠癌 (CRC) 查的准确性,即使在邮件运输过程中短时间暴露于高温. 这支持在温暖的月份继续进行CRC查.
科学领域:
- 大肠直肠癌 (CRC) 查
- 临床诊断 临床诊断 临床诊断
- 生物化学分析 生物化学分析
背景情况:
- 便免疫化学测试 (FIT) 对于结直肠癌 (CRC) 查至关重要.
- 升高的温度可以通过降低血红蛋白 (Hb) 来损害FIT准确性.
- 在FIT缓冲器中的稳定剂旨在减轻与温度相关的Hb降解,但它们的有效性需要验证.
研究的目的:
- 为了评估高温 (>30°C) 对OC-Sensor FIT Hb度的影响.
- 为了描述邮件运输期间的FIT温度.
- 在CRC查程序中评估环境温度对FIT Hb度的影响.
主要方法:
- 在不同温度下试验室内化FIT以测量Hb度.
- 使用数据记录器记录邮件运输期间的FIT温度.
- 用回归模型分析选计划数据,以将环境变量与FIT温度和Hb度相关联.
主要成果:
- 在30°C以上的实验室化时间超过4天,FIT Hb度下降.
- 在运输过程中,FIT体验了平均比环境温度高6.4°C的温度,不到24小时超过30°C.
- 查计划数据显示,FIT Hb度与最大环境温度之间没有显著的关联.
结论:
- 在邮件运输过程中,短时间暴露于高温并不能显著降低FIT Hb度.
- 带有稳定剂的现代FIT在温暖的天气中可靠进行CRC查,前提是邮件交付时间在4天内.
- 这些发现支持继续使用FIT进行全年CRC查.
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