美国成年人NT-proBNP和全因和心血管死亡率:一项前性队列研究
Justin B Echouffo-Tcheugui1, Sui Zhang2, Natalie Daya2
1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine Johns Hopkins University Baltimore MD.
N-终端亲B型尿素 (NT-proBNP) 预测了美国一般成年人群的死亡风险. 较高的NT-proBNP水平与所有原因和心血管疾病死亡率的增加有关,无论人口因素如何.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 公共卫生 公共卫生
背景情况:
- N-终端亲B型尿素 (NT-proBNP) 是心力衰竭患者已知的死亡率预测因子.
- 以前的研究表明,NT-proBNP的预后价值在门诊成年人中,主要是在老年人群中.
研究的目的:
- 评估NT-proBNP水平与美国成年人群中所有原因和心血管疾病 (CVD) 死亡率之间的关联.
- 为了检查这些协会在各种人口学子组,包括年龄,种族/种族和体重指数.
主要方法:
- 使用1999-2004年国家健康和营养检查调查 (NHANES) 的数据进行前性队列分析.
- 包括10645名20岁以上的美国成年人,随访时间到2019年.
- 考克斯回归模型用于分析NT-proBNP与死亡率的关联,并对混因素进行调整.
主要成果:
- 在以前没有心血管疾病的个体中,高NT-proBNP (≥75百分位数) 与较高的全因死亡率 (HR 1.67) 和心血管疾病死亡率 (HR 2.87) 显著相关.
- 这些关联在根据年龄,性别,种族/种族和BMI (所有P相互作用>0.05) 定义的子组中保持一致.
结论:
- 在美国成年人中,NT-proBNP是所有原因和心血管疾病死亡率的独立风险因素.
- 在更广泛的成年人群中,NT-proBNP可能成为监测风险的有价值工具.
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