在患有多发性硬化症的孕妇中,SARS-CoV2感染
Maria Grazia Aprea1, Irene Schiavetti2, Emilio Portaccio1
1Department of NEUROFARBA, University of Florence, Florence, Italy.
概括
患有多发性硬化症 (MS) 的孕妇不会面临严重COVID-19结果的更高风险. 在这项研究中,感染前的接种疫苗和怀孕本身并不是严重的COVID-19的重要风险因素.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 产科 产科 产科 产科 产科
背景情况:
- 孕妇在怀孕期间感染SARS-CoV-2可能会导致母亲的不良结果.
- 以前的研究表明,患有多发性硬化症的孕妇和产后妇女的严重COVID-19风险没有增加.
研究的目的:
- 在被诊断患有多发性硬化症的孕妇患者中评估COVID-19的临床结果.
- 在这个特定人群中确定与严重的COVID-19相关的风险因素.
主要方法:
- 一项多中心研究涉及85名患有多发性硬化症的孕妇患者,这些患者感染了COVID-19.
- 与来自MuSC-19数据库的1354名女性的对照组进行了比较.
- 后勤回归模型用于识别严重COVID-19 (住院,ICU入院或死亡) 的预测因素.
主要成果:
- 严重的COVID-19的独立预测因素包括晚年,BMI≥30,抗CD20治疗和最近的甲基prednisolone使用.
- 感染前的疫苗接种表明具有保护作用.
- 怀孕既不是严重COVID-19的风险因素,也不是保护因素.
结论:
- 患有多发性硬化症的孕妇没有经历严重的COVID-19结果的显著增加风险.
- 研究结果强调了疫苗接种和在疫情期间在怀孕的多发性硬化患者中管理并发性疾病的重要性.
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