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硫素1是减轻人类ARPE19细胞中糖尿病诱导的RPE细胞功能障碍的目标,通过减轻氧化应激

Hui Qi1, Tianhe Liu1, Jiasu Liu1

  • 1Department of Histology and Embryology, College of Basic Medicine, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.

Molecular medicine reports
|May 26, 2023
PubMed
概括

过度表达的 thioredoxin 1 (Trx1) 通过减少氧化应激和改善视网膜色素上皮细胞功能来缓解糖尿病视网膜病变. 这项研究澄清了Trx1的情况.

关键词:
灭症 (apoptosis) 是一种死亡的过程.糖尿病视网膜病变 糖尿病视网膜病变氧化应激是一种氧化应激.视网膜色素表皮质是视网膜色素表皮质.甲素1 甲素1 是一种

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Regulation of the Unfolded Protein Response01:31

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...