Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genomics02:02

Genomics

36.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Interplays of mutations in <i>waaA</i>, <i>cmk</i>, and <i>ail</i> contribute to phage resistance in <i>Yersinia pestis</i>.

Frontiers in cellular and infection microbiology·2023
Same author

Mitochondrial quality control in cardiac fibrosis: Epigenetic mechanisms and therapeutic strategies.

Metabolism: clinical and experimental·2023
Same author

Efficacy and Safety of Pembrolizumab Monotherapy for Recurrent/Unresectable/Metastatic Oral Squamous Cell Carcinoma: A Single-Center Study in China.

Journal of oncology·2023
Same author

Dietary n-3/n-6 polyunsaturated fatty acid ratio modulates growth performance in spotted seabass (<i>Lateolabrax maculatus</i>) through regulating lipid metabolism, hepatic antioxidant capacity and intestinal health.

Animal nutrition (Zhongguo xu mu shou yi xue hui)·2023
Same author

A method for restoring signals and revealing individual macromolecule states in cryo-ET, REST.

Nature communications·2023
Same author

Hypertriglyceridemia as a risk factor for complications of acute pancreatitis and the development of a severity prediction model.

HPB : the official journal of the International Hepato Pancreato Biliary Association·2023

相关实验视频

Updated: Jul 29, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.5K

ProgCAE:一种基于深度学习的方法,集成了多omics数据来预测癌症亚型.

Qingchun Liu1, Kai Song1

  • 1School of Mathematics and Statistics, Qingdao University, Qingdao, China.

Briefings in bioinformatics
|May 26, 2023
PubMed
概括
此摘要是机器生成的。

这项研究介绍了ProgCAE,一种使用多omics数据的深度学习模型,用于识别癌症亚型并预测患者的生存率. ProgCAE准确地识别了与生存相关的癌症亚型,优于传统方法.

关键词:
癌症亚型 癌症亚型深度学习是一种深度学习.多种主题的多种主题.预后 预后 预后幸存率 幸存率 生存率

更多相关视频

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.4K
Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.2K

相关实验视频

Last Updated: Jul 29, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.5K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.4K
Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.2K

科学领域:

  • 在瘤学瘤学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 准确的癌症亚型和预后对于有效的癌症研究和治疗至关重要.
  • 高通量测序产生了大量的多omics数据,这是了解癌症异质性的宝贵资源.
  • 深度学习为整合复杂的多omics数据提供了强大的工具,以发现新的癌症亚型.

研究的目的:

  • 开发和验证一种新的预后模型,用于预测与患者生存相关的癌症亚型.
  • 利用深度学习,特别是卷积自编码器,对多omics癌症数据进行增强分析.
  • 证明拟议模型在多种癌症类型中识别临床相关的癌症亚型的实用性.

主要方法:

  • 开发一个名为 ProgCAE 的预测模型,基于卷积自编码器架构.
  • 应用ProgCAE集成多omics数据来预测癌症亚型.
  • 验证ProgCAE在识别12种癌症类型中具有显著生存差异的癌症亚型方面的表现.
  • 将 ProgCAE 的预后预测与传统的统计方法进行比较.

主要成果:

  • 在12种不同的癌症类型中,ProgCAE成功预测了与显著生存差异相关的癌症亚型.
  • 与传统的统计方法相比,拟议的模型在预测大多数癌症类型的患者存活率方面表现优越.
  • 已识别的亚型是稳固的,适合构建下游监督分类器以进一步临床应用.

结论:

  • 基于卷积自编码器的预后模型 (ProgCAE) 有效地识别了与生存结果相关的癌症亚型,使用多omics数据.
  • 在癌症亚型和预后预测方面,ProgCAE代表了一项进步,其表现优于传统方法.
  • 该模型预测亚型的能力使得开发更准确的生存预测工具和个性化癌症治疗成为可能.