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性别和年龄对健康的牙转录基因组模式的影响
J L Ebersole1, S S Kirakodu2, L M Nguyen1
1Department of Biomedical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, NV, USA.
Journal of dental research
|May 26, 2023
概括
性别和年龄显著影响牙组织基因表达,影响牙周炎风险. 这些基于性别的生物学差异在生命早期出现,影响免疫和结构基因模式.
科学领域:
- 口腔生物学 口腔生物学
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 慢性炎症性疾病,包括牙周炎,表现出人口统计学关联,如性别和年龄.
- 牙周炎的患病率随着年龄的增长而增加,在男性中更高.
研究的目的:
- 研究非人类灵长类动物健康的牙转录组的性别和年龄相关差异.
- 将基因表达模式与牙周炎的临床测量相关联,例如探针出血 (BOP) 和探针口袋深度 (PPD).
主要方法:
- 在四个年龄组 (年轻人,青少年,成年人,老年人) 中对36只Macaca mulatta的牙组织基因表达的分析.
- 根据性别和年龄对转录组数据的分层.
- 基因表达与临床BOP和PPD测量的比较.
主要成果:
- 在基因表达方面观察到显著的性别差异,随着年龄的增长而增加.
- 雌性显示出高调的免疫/炎症反应基因;雄性显示出高调的组织结构基因.
- 性别之间的基因表达与BOP/PPD的相关性不同,男性显示出大量的重叠.
结论:
- 牙生物学存在大量的与性别相关的变化,受年龄的影响,甚至在青少年中也可以检测到.
- 与性相关的牙组织的早期"编程"可能会使个人易患牙周炎.
- 性别和年龄是理解牙组织恒常性和牙周炎易感性的关键因素.
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