乳腺囊括性乳头皮质癌:它是否具有本地基底膜?
Suzan F Ghannam1,2,3, Catrin S Rutland4, Cinzia Allegrucci3,4
1Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, UK.
Histopathology
|May 26, 2023
概括
封装的乳头皮质癌 (EPC) 囊是一种反应性树皮过程,而不是加厚的底层膜 (BM). 这一发现表明EPC是一种惰的侵入性癌瘤,与正常和现场病变不同.
科学领域:
- 病理学 病理学 病理学
- 在瘤学瘤学.
- 生物材料科学 生物材料科学
背景情况:
- 封装乳头癌 (EPC) 呈现出一个囊,经常被误认为是加厚的底层膜 (BM).
- 区分囊的起源对于了解EPC的性质至关重要.
研究的目的:
- 分析EPC囊的几何和原特性.
- 为了确定EPC囊是否代表扩张的BM或树皮反应.
主要方法:
- 100例乳腺组织病例 (EPC,DCIS,正常,侵入性) 和甲状腺癌的比较分析.
- 皮克罗西里乌斯红色染色和极化显微镜用于原蛋白分析.
- 使用专门的软件进行图像分析 (ImageJ,CT-FIRE,Curve align).
主要成果:
- 与正常/DCIS BM相比,EPC囊表现出较大的原宽度,直度,密度和减少的长度.
- EPC囊显示不组织的I型原体,更大的异质性,和较少的纤维对齐比正常/DCIS BM.
- EPC囊与侵入性瘤BM有相似之处,但与正常/DCISBM和EPTC不同.
结论:
- EPC囊是一种反应性树过程,而不是加厚的本地BM.
- 囊的特征支持将EPC归类为一种惰性侵入性癌瘤.
- 这种区分对于准确的诊断和治疗策略至关重要.
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