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用于抑制和调节莱克的糖仿制药

Steffen Leusmann^1,2,3, Petra Ménová⁴, Elena Shanin^5,6

¹Chemical Biology of Carbohydrates (CBCH), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, 66123 Saarbrücken, Germany. alexander.titz@helmholtz-hzi.de.

Chemical Society reviews

|May 26, 2023

概括

糖相对应抑制剂通过干扰碳水化合物识别提供了新的治疗策略. 这些小分子模仿天然的碳水化合物相互作用,促进了涉及莱克的疾病的治疗方法.

科学领域:

葡萄糖生物学和药物化学
碳水化合物-蛋白质相互作用
治疗开发的治疗方法.

背景情况:

碳水化合物调解关键的生物过程,包括免疫反应,细胞通信和感染.
碳水化合物结合蛋白,称为乳蛋白,是这些功能的核心.
干扰碳水化合物识别是一个有前途的治疗途径.

研究的目的:

审查糖相传抑制剂的设计原则.
突出干扰莱克功能的策略.
总结了糖相对应设计和各种莱克类的应用方面的进展.

主要方法:

对糖相对应抑制剂的一般设计原则的审查.
对三种方法的讨论:碳水化合物衍生型甘油仿真药,新型支架和全调节剂.
概述了最近在糖相对应设计和哺乳动物,病毒和细菌学菌素的应用方面取得的进展.

主要成果:

甘油仿真药作为基础研究工具和治疗方法具有前景.
介绍了已经进入临床试验或市场的糖仿制药的例子.
讨论了针对性蛋白质降解和输送中的新兴应用.

结论:

葡萄糖相对应抑制剂是针对碳水化合物识别的多功能疗法.
设计和应用方面的进步为治疗涉及莱克的疾病提供了新的可能性.
糖仿制药正在扩展到新的领域,如向蛋白质降解和输送.

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