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目前的分子,细胞和遗传方面的围植入炎疾病:一个叙事审查

Marek Chmielewski¹, Andrea Pilloni²

¹Private Practice, 80-280 Gdańsk, Poland.

Dentistry journal

|May 26, 2023

概括

周植入炎涉及复杂的细胞和遗传因素,关键细胞因子如IL-6和IL-1β在它的发展和诊断中起着重要作用. 现在的进展为患者提供了更好的风险预测和治疗理解.

科学领域:

牙科植入物学牙科植入物学
牙周病学牙周病学
免疫学免疫学免疫学

背景情况:

周植入体炎是一种多因素的炎症状况,影响牙植入体周围的组织.
最近的研究扩大了对其细胞,分子和遗传基础的理解.
本综述综合了过去二十年关于围植入炎的当前知识.

研究的目的:

总结有关围植入炎的现有文献.
突出了解其病原和风险因素的最新进展.
为了确定关键的细胞和分子参与者.

主要方法:

在Embase和PubMed.com上进行了全面的文献搜索.
关键词包括"周植入炎"",细胞因子"",遗传"",细胞"和"危险因素".
在选3013个初步结果后,选出了55篇相关文章.

主要成果:

介质素-6 (IL-6),IL-1β,瘤坏死因子-α (TNF-α) 和矩阵金属蛋白酶-8 (MMP-8),以及它们的遗传变异,在围植入炎病原和诊断中至关重要.
表皮细胞,炎症细胞和骨系细胞是疾病过程的核心.
特定的细胞因子和遗传因素与疾病发展密切相关.

结论:

周植入炎涉及各种各样的细胞,细胞因子和遗传变异.
新的诊断工具正在出现,以更好地了解患者的反应,并预测疾病风险.
持续的研究对于改善患者的治疗结果和管理植入周围疾病至关重要.

关键词:

细胞反应的细胞反应.细胞因子细胞因子遗传多形态主义是一种遗传多形态主义.这是一种炎症炎症炎症炎症.分子因素分子因素.周植入体炎 (Peri-implantitis) 是一种疾病,

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