在门癌症的免疫疗法
Natasha Dhawan1, Muhammad Z Afzal1, Manik Amin1
1Department of Medical Oncology, Dartmouth Cancer Center, Lebanon, NH 03756, USA.
Current oncology (Toronto, Ont.)
|May 26, 2023
概括
免疫疗法正在成为门癌症,特别是状细胞癌的关键治疗方法. 研究重点是将检查点抑制剂和疫苗等免疫疗法整合到各种治疗阶段.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 在全球范围内,门状细胞癌的发病率和死亡率正在上升.
- 高风险的人类乳头瘤病毒 (HPV) 感染与大多数门癌症有关.
- HPV 型蛋白 E6 和 E7 可以引起抗瘤免疫反应.
研究的目的:
- 审查免疫疗法在治疗状细胞癌中的不断变化的作用.
- 总结目前的研究和未来的免疫疗法在门癌症治疗的方向.
主要方法:
- 对癌治疗方法的当前文献的综述.
- 分析人类乳头瘤病毒 (HPV) 对抗瘤免疫力的影响.
- 探索正在研究的各种免疫疗法策略.
主要成果:
- 免疫疗法,包括免疫检查点抑制剂,采用细胞疗法和疫苗,对门癌症有很大的希望.
- 目前正在探索结合免疫调节非免疫疗法的组合疗法.
- 研究人员正在积极研究门癌不同阶段的免疫疗法测序.
结论:
- 免疫疗法代表了癌治疗模式的重大进步.
- 进一步的研究至关重要,以优化免疫疗法在本地先进和转移的环境中使用.
- 整合免疫疗法策略有可能改善腔状细胞癌患者的治疗结果.
相关概念视频
Tumor Immunotherapy
584
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
584
Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
Cancer Vaccines
447
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
447
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Combination Therapies and Personalized Medicine
5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
207
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
207


