免疫检查点抑制剂的不良影响:以成像为导向的综合性审查
Carlo Augusto Mallio1,2, Caterina Bernetti1,2, Laura Cea1,2
1Department of Medicine and Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.
Current oncology (Toronto, Ont.)
|May 26, 2023
概括
免疫检查点抑制剂 (ICI) 可以导致影响各种器官的免疫相关不良事件 (irAEs). 通过成像早期识别irAEs对于及时的患者管理和治疗至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- 免疫检查点抑制剂 (ICI) 是增强抗瘤免疫力的单克隆抗体.
- ICI用于高级恶性瘤,包括黑色素瘤,肺癌和结直肠癌.
- 副作用被称为免疫相关不良事件 (irAEs),通常影响皮肤,肠道,肝脏和内分泌系统.
研究的目的:
- 审查iRAE的放射性征兆和差异诊断.
- 提供指导,以识别主要IRAE的关键放射性发现.
- 强调成像在早期irAE诊断和管理中的作用.
主要方法:
- 对IRE的放射性征兆和临床模式的审查.
- 基于涉及的器官系统进行分析.
- 考虑irAE发生率,严重程度和成像的诊断作用.
主要成果:
- ICI可以导致多个器官系统的多样化irAEs.
- 放射学发现对于将IRE与其他疾病区分开来至关重要.
- 通过成像早期识别irAEs有助于迅速干预.
结论:
- 充分了解irAEs的成像和临床特征是必不可少的.
- 放射学在早期诊断和治疗irAEs中发挥着关键作用.
- 及时识别irAEs可以确保适当的患者护理和治疗调整.
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