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iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Updated: Jun 18, 2026

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

微环境重要:芯片上的大脑技术的进步

Gulden Akcay¹, Regina Luttge^1,2,3

¹Neuro-Nanoscale Engineering, Department of Mechanical Engineering/Microsystems, Institute of Complex Molecular Systems, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.

|May 26, 2023

概括

工程微环境和脑体提供先进的体外模型,以了解大脑结构和功能. 这些方法克服了研究健康和疾病大脑状态的组成和功能方面的挑战.

关键词:

在芯片上的大脑有教训性的微环境.微型制造是指微型制造.

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Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

相关实验视频

Last Updated: Jun 18, 2026

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

科学领域:

神经科学是一个神经科学.
生物材料工程生物材料工程
干细胞生物学干细胞生物学

背景情况:

人类大脑的复杂组织需要先进的建模技术.
了解区域度梯度和细胞多样性对于大脑仿真至关重要.
机械特性显著影响神经元细胞的反应.

研究的目的:

审查用于大脑建模的工程教学微环境的最先进技术.
为了突出体外大脑仿真的基本参数.
讨论模拟大脑组成和功能方面的进展.

主要方法:

关于工程教学微环境的当前文献的综述.
从人类衍生的多能干细胞 (hPSCs) 衍生的脑的分析.
集成的brainoids与脑在芯片 (BoC) 平台和3D打印的凝.

主要成果:

工程微环境和脑机代表了大脑建模的重大飞跃.
先进的体外试验方法提供了更好的成本效益,易用性和可用性.
这些平台有助于研究神经元对机械性质的反应.

结论:

在芯片上的大脑技术中推进教学微环境的新视角.
增强对健康和疾病状态中大脑细胞功能的理解.
审查的方法为未来的体外大脑研究提供了基础.