基于乳液的凝装载着布洛芬及其衍生物
Adebukola Abiola Agboola1, Anna Nowak2, Wiktoria Duchnik2
1Department of Chemical Organic Technology and Polymeric Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Ave. 42, 71-065 Szczecin, Poland.
Gels (Basel, Switzerland)
|May 26, 2023
概括
这项研究开发了一种基于乳液的凝,用于增强布洛芬 (IBU) 和其衍生物的通过皮肤递送. 与商业产品相比,新型配方显著改善了皮肤透率,提供了更快的药物输送系统.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 皮肤病学 皮肤病学
背景情况:
- 通过皮肤输送的药物提供优势,而不是通过口服的非类固醇抗炎药物,如布洛芬 (IBU).
- 优化载体配方和活性化合物的化学修饰对于提高皮肤透度至关重要.
研究的目的:
- 评估载体和化学修改对伊布罗芬皮肤透和积累的影响.
- 开发和描述新型的半固体配方,以改善布洛芬及其衍生物的通过皮肤输送.
主要方法:
- 开发基于乳液的凝配方,其中含有易布洛芬,易布洛芬酸 (IBUNa) 和L-phenylalanine乙烯基易布洛芬酸 ([PheOEt][IBU]).
- 配方性质的表征:密度,折射率,粘度和颗粒大小分布.
- 使用猪和人类皮肤模型进行体外透研究,以评估药物释放和皮肤透.
主要成果:
- 与商业凝和奶油配方相比,基于乳液的凝显著提高了易布洛芬及其衍生物的皮肤透率.
- 在24小时浸透后,布洛芬的累积质量是基于乳液的凝的1.6-4.0倍.
- 布洛芬衍生物 (IBUNa和[PheOEt][IBU]) 显示出强大的皮肤透增强特性.
结论:
- 基于透皮乳液的凝载体,结合药物的化学修饰,是加速药物输送的有希望的方法.
- 开发的配方显示出更有效地通过皮肤给药布洛芬和相关化合物的潜力.
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