在体外和在体内描述含有黄素的奇托-PVA水凝:抗菌和潜在的伤口愈合活性
Hitesh Chopra1, Shabana Bibi2,3, Yugal Kishore Mohanta4
1Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.
Gels (Basel, Switzerland)
|May 26, 2023
概括
这项研究开发了一种基于黄素的水凝,显示出显著的抗微生物和伤口愈合潜力. 素-PVA-黄素水凝提供持续释放和有前途的体外和体内结果,用于伤口护理应用.
科学领域:
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
- 传统医学的传统医学.
背景情况:
- 黄是一种来自黄的化合物,在传统医学中有着悠久的历史.
- 开发有效的局部递送系统对于黄素的治疗应用至关重要.
- 自然化合物的抗微生物和伤口愈合特性具有重大研究兴趣.
研究的目的:
- 开发一种基于黄素的新水凝系统.
- 评估水凝的抗微生物和伤口愈合 (WH) 潜力.
- 用"体外"和"体内"的方法来评估水凝的疗效.
主要方法:
- 使用奇托,聚乙烯醇 (PVA) 和黄素制备局部水凝.
- 评估水凝的物理化学性质.
- 在体外对抗菌素测试针对阳性和阴性细菌.
- 在基分子对接研究中,预测与炎症蛋白的相互作用.
- 在体外溶解研究以评估黄素释放动力学.
主要成果:
- 开发的奇托-PVA-库尔库水凝表现出有利的物理化学特性.
- 对一系列微生物观察到显著的抗菌活性.
- 在分析显示,黄素与参与伤口愈合的关键蛋白质的良好结合相互作用.
- 从水凝基质中持续释放的黄素得到证实.
结论:
- 奇托-PVA-黄素水凝显示出有前途的抗微生物和伤口愈合潜力.
- 该配方适合局部应用,并提供持续的药物输送.
- 需要进一步的体内研究来证实治疗伤口的临床疗效.
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