性溶剂类型和pH对来自Eucheuma cottonii的卡拉济南固体物理性能的影响
Rival Ferdiansyah1,2, Marline Abdassah3, Achmad Zainuddin4
1Doctoral Program, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia.
Gels (Basel, Switzerland)
|May 26, 2023
概括
这项研究探讨了类型和pH值如何影响卡拉基.
科学领域:
- 海洋生物技术 海洋生物技术
- 聚合物科学 聚合物科学
- 材料科学 材料科学 材料科学
背景情况:
- 红藻中的多糖体卡拉基南在食品和制药中广泛使用.
- 以前的研究集中在卡拉基南的一般物理性质上.
- 处理对固态特性的影响仍然不太清楚.
研究的目的:
- 研究不同类型 (NaOH,KOH,Ca(OH) 2) 和pH值对卡拉基南固态物理性质的影响.
- 为潜在的药物应用确定卡拉基修饰的最佳条件.
主要方法:
- 在9,11和13的pH值下使用NaOH,KOH和Ca(OH) 2从Eucheuma cottonii提取卡拉基南.
- 预先属性的表征 (产量,灰,硫酸盐含量,粘度,凝强度).
- 分析固体特性,包括分子量,FTIR,形态,晶度,密度,固体分数,拉伸强度,粘合指数,脆裂指数和水溶性.
主要成果:
- 所有卡拉基南样本都符合粮农组织的规格.
- 类型显著影响了膨胀能力,分子量,结晶度,密度,抗拉强度和可溶性.
- (OH) 2处理导致更结晶,立方形的卡拉基南,具有更高的结晶度和密度.
- 通过KOH处理,可以获得具有更高拉伸强度和固体分数的卡拉基.
- NaOH处理提高了水溶性.
结论:
- 类型和pH值是修改卡拉基南固态特性的关键因素.
- 使用Ca(OH) 2获得的卡拉基具有独特的晶体和形态特征.
- 这些发现为为固体剂型开发量身定制的卡拉基南辅助剂提供了基础.
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