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Updated: Jul 29, 2025

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
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使用多变量模型更新化学方法在尖的人类血中确定gemcitabine和sorafenib

Marco M Z Sharkawi1, Norhan R Mohamed2, Mohammed T El-Saadi2,3

  • 1Beni-Suef University, Faculty of Pharmacy, Pharmaceutical Analytical Chemistry Department, Alshaheed Shehata Ahmed Hegazy St., Beni-Suef 62514, Egypt.

Journal of AOAC International
|May 26, 2023
PubMed
概括

这项研究引入了快速,准确的化学测量方法,用于同时测量人类血中的gemcitabine (GEM) 和sorafenib (SOR). 这些技术为癌症药物分析提供了具有成本效益的质量控制.

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相关概念视频

Protein-Drug Binding: Determination Methods01:22

Protein-Drug Binding: Determination Methods

Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
Indirect methods involve isolating the bound drug from its free form in biological samples such as blood, serum, or plasma. These techniques aim to measure the percentage of drugs bound to proteins. Equilibrium dialysis is a commonly used method where the free drug concentration at equilibrium is measured by separating the bound...
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