对Sanghuangporus sanghuang的基因组重新注释和转录组分析
Zi-Qi Shen1,2,3, Ji-Hang Jiang2, Chang-Tian Li1
1Internationally Cooperative Research Center of China for New Germplasm Breading of Edible Mushroom, Ministry of Science and Technology, Changchun 130118, China.
Journal of fungi (Basel, Switzerland)
|May 26, 2023
概括
这项研究提出了一个改进的基因组组装为Sanghuangporus sanghuang,一种药用真菌. 增强的基因组揭示了更多的药用基因,有助于理解它的进化和代谢产物.
科学领域:
- 菌类学 菌类学是指菌类学.
- 基因组学就是基因组学.
- 药用真菌是一种药用真菌.
背景情况:
- 桑黄 (Sanghuangporus sanghuang) 是一种有价值的药用真菌,具有重要的商业潜力.
- 了解其遗传构成对于医疗应用至关重要.
研究的目的:
- 改进Sanghuangporus sanghuang菌株MS2的基因组组装和注释.
- 识别与药物功能相关的基因并分析代谢物.
主要方法:
- 从S. sanghuang菌株MS2中新生成的转录组序列.
- 结合现有的基因组序列和UniProtKB/Swiss-Prot数据库.
- 采用了一种用于基因组组装和注释的新方法.
主要成果:
- 在更新的基因组中共发现了13531个蛋白质编码基因.
- 实现了92.8%的完整BUSCOs,表明基因组准确性和完整性得到了改善.
- 与原版相比,注释了更多与药用功能相关的基因,并根据转录组数据进行了验证.
结论:
- 增强的基因组和转录组数据为S. sanghuang的进化提供了宝贵的见解.
- 有助于进一步研究这种真菌的代谢物和药用应用.
更多相关视频
10:40Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
Published on: December 22, 2017
10.6K
04:22Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
Published on: May 20, 2024
913
相关概念视频
Genome Annotation and Assembly
19.0K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
19.0K
Genome-wide Association Studies-GWAS
13.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.7K
