介绍一下真菌过敏:Alternaria alternata及其过敏原
Eva Abel-Fernández1, María José Martínez1, Tania Galán1
1Applied Science, Inmunotek S.L., Parque Científico Tecnológico Alcalá de Henares, 28805 Madrid, Spain.
Journal of fungi (Basel, Switzerland)
|May 26, 2023
概括
性过敏,特别是来自Alternaria的过敏,是呼吸系统问题和喘的主要原因. 改善诊断需要组件解决的策略,而不仅仅是Alt a 1,还需要考虑其他Alternaria过敏原,如Eolase和MnSOD.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 环境健康 环境健康
- 菌类学 菌类学是指菌类学.
背景情况:
- 菌类过敏是呼吸系统疾病的重要原因,与喘预后不佳密切相关.
- 阿尔特纳里亚和克拉多斯波里亚是过敏呼吸道疾病中的关键品种,阿尔特纳里亚敏感性非常普遍.
- 暴露于Alternaria过敏原发生在室外和室内,子和碎片作为气体过敏源.
研究的目的:
- 为突出诊断由于非标准化提取物的真菌过敏所面临的挑战.
- 强调对Alternaria过敏的组件解决诊断策略的需要.
- 讨论 Alternaria alternata 的已知和潜在的过敏原.
主要方法:
- 关于真菌过敏原,特别是Alternaria的当前文献的综述.
- 通过WHO/IUIS和其他数据库对被接受和建议的Alternaria过敏原进行分析.
- 讨论使用原始过敏原提取物的传统诊断方法的局限性.
主要成果:
- 已知有12种Alternaria alternata过敏原,其中许多是酶 (例如,酶,MnSOD) 或具有结构性/调节性功能.
- Alt a1是主要的过敏原,但其他如酶 (Alt a6) 和MnSOD (Alt a14) 都被建议用于诊断面板.
- 目前的诊断和治疗提取物是可变的,并没有得到足够的标准化.
结论:
- 对真菌过敏的诊断是复杂的,并且由于缺乏标准化组件而受到阻碍.
- 组件解决的诊断策略对于准确的真菌过敏评估至关重要.
- 为了改善临床管理,需要对Alternaria过敏原进行进一步的研究和标准化.
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