当用于多根牙的根管消毒时,二凝和水溶液的微生物学有效性:一项随机临床研究
Niral Kotecha1, Nimisha Chinmay Shah1, Rohan Jiteshkumar Doshi1
1Department of Conservative Dentistry and Endodontics, K M Shah Dental College and Hospital Sumandeep Vidyapeeth, Pipariya, Waghodia, Vadodara 391760, Gujarat, India.
Journal of functional biomaterials
|May 26, 2023
概括
低化凝及其水溶液在消毒多根牙的根通道和初级内牙病变中表现出类似的抗菌效果. 这一发现支持凝形式的存在.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 微生物学 微生物学
- 牙科材料科学 牙科材料科学
背景情况:
- 内牙治疗的目的是从根管系统中消除微生物.
- 低酸 (NaOCl) 是一种标准的灌剂,但对周围组织可能具有细胞毒性,限制其在特定临床情况下的使用.
- 一种NaOCl的凝配方可以提供一种具有潜在降低细胞毒性的替代品,同时保持有效性.
研究的目的:
- 在微生物学上评估5.25%的低化凝与其水溶液相比,作为根管消毒剂的有效性.
- 在多根牙中评估抗微生物活性,具有初级内牙病变.
主要方法:
- 一项随机对照研究,涉及42名多根牙患者,需要内牙治疗.
- 术前 (S1) 和术后 (S2) 的微生物样本从根管中收集.
- 牙被随机分为两组:用5.25%的NaOCl凝 (A组) 或水溶液 (B组) 消毒.
- 在化后确定了殖民地形成单位 (CFU),并进行了统计分析 (曼-惠特尼U测试).
主要成果:
- 在5.25%的低化凝和水溶液组之间的平均殖民地形成单位数量差异中没有发现统计学上显著的差异 (p = 0.744).
- 两种配方都在减少根通道中的微生物负载方面表现出相似的抗菌有效性.
结论:
- 5.25%的低酸凝表现出与其水溶液相匹配的抗菌效果,当它作为多根牙的根管消毒剂用于具有初级内牙病变的多根牙时.
- 在临床场景中,凝形式可能是一个可行的替代方案,在临床场景中,水溶液的细胞毒性作用是令人担忧的.
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