细胞对和蛋白质调节的反应:一个体外研究
Qiang Zhi1,2,3, Yuehua Zhang2,3,4, Jianxu Wei1,2,3
1Department of Implant Dentistry, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Journal of functional biomaterials
|May 26, 2023
概括
用纤维素素调节的补充,通过抑制有害细菌并促进有益细胞生长,有效地预防周植入炎,为牙植入物感染提供了有前途的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 表面工程是什么?表面工程是什么?
背景情况:
- 牙植入物是牙替代的主要选择.
- 牙周植入物感染对牙科植入物成功构成重大挑战.
- 制定预防周植入炎的策略对于临床结果至关重要.
研究的目的:
- 为了开发一种新的添加的表面.
- 为了研究纤维素调节对表面的影响.
- 评估该材料在预防周植入炎病原体的有效性,同时支持宿主细胞.
主要方法:
- 使用热和电子束蒸发制造加的.
- 用人体血纤维素原来调节表面.
- 评估表面的水友性和释放的.
- 评估病原体殖民 (Streptococcus mutans, Porphyromonas gingivalis) 和人类牙纤维细胞 (hGFs) 的粘附和生长.
主要成果:
- 制造的含有12.8±1.8%的,增加了表面的水友性.
- 在纤维素原条件下释放的会改变蛋白质结构.
- 修改后的表面抑制了与围植入炎相关的病原体的殖民.
- 该材料支持人类牙纤维细胞的粘附和生长.
结论:
- 结合兴奋剂和纤维素调节,为牙科植入物创造了一个有前途的生物材料.
- 这种方法提供了一种抑制周植入炎的策略.
- 修改后的表面显示出牙科植入物改善临床性能的潜力.
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