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直接写入电功能化支架用于牙周再生:在体外研究.

Laura Bourdon1, Nina Attik1,2, Liza Belkessam1,2

  • 1Laboratoire des Multimatériaux et Interfaces, UMR 5615, CNRS, Université Claude Bernard Lyon 1, Bâtiment Chevreul, 6 Rue Victor Grignard, 69622 Villeurbanne, France.

Journal of functional biomaterials
|May 26, 2023
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概括
此摘要是机器生成的。

直接编写电制造了用于牙周再生的功能性支架. 这些支架含有氧酸纳米颗粒或水泥蛋白1的,成功支持细胞生长和矿化,显示复杂组织修复的希望.

关键词:
在CEMP1中.这是一个双功能双功能.细胞矿化细胞矿化直接写信是一种直接写信.电力旋转是指电力旋转.基亚帕提特纳米颗粒 基亚帕提特纳米粒子牙周结带细胞是牙周结带细胞.牙周再生 牙周再生脚手架的脚手架是一个脚手架.

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科学领域:

  • 生物材料科学 生物材料科学
  • 组织工程是组织工程.
  • 再生医学是一种再生医学.

背景情况:

  • 多相支架是复杂组织再生的理想选择,如周期性支架.
  • 现有的脚手架往往缺乏建筑精度,涉及复杂的制造,阻碍临床使用.
  • 直接编写电 (DWE) 提供了一个快速的方法来创建具有受控架构的3D支架.

研究的目的:

  • 开发一种使用DWE进行牙周再生的双相支架.
  • 将酸纳米颗粒 (HAP) 和水泥蛋白1 (CEMP1) 纳入骨和水泥再生.
  • 为了评估脚手架对牙周带 (PDL) 细胞行为的影响.

主要方法:

  • 使用DWE与两个聚烯溶液制造双相支架.
  • 使用HAP纳米颗粒和CEMP1.1.的脚手架部分的功能化.
  • 脚手架的形态特征.
  • 在支架上评估PDL细胞的增殖,殖民和矿化.

主要成果:

  • 通过使用DWE,在受控架构下成功制造了脚手架.
  • 这两种HAP和CEMP1功能化的支架都支持PDL细胞殖民.
  • 与非功能化对照组相比,功能化支架表现出增强的矿化,由阿利沙林红色染色和OPN表达证实.

结论:

  • 功能化,有组织的脚手架显示了刺激骨和骨再生的潜力.
  • DWE是一种可行的技术,用于创建具有受控细胞定向的智能支架,用于组织再生.
  • 这种方法可以显著推进牙周和其他复杂组织再生策略.