非酒精性脂肪肝和结直肠癌之间的关联:一个基于人口的研究
Po-Hsien Wu1, Chi-Hsiang Chung2,3,4, Ying-Hsiang Wang1
1Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Medicine
|May 26, 2023
概括
非酒精性脂肪肝 (NAFLD) 与患结直肠癌 (CRC) 的风险更高有关. 这项研究发现,在NAFLD患者中,CRC发病率显著增加,特别是那些患有糖尿病或慢性肝病的50岁以上患者.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 非酒精性脂肪肝 (NAFLD) 和结直肠癌 (CRC) 是普遍存在的全球健康问题.
- NAFLD和CRC之间的关系仍然存在争议,需要进一步调查.
研究的目的:
- 调查NAFLD与患CRC的风险之间的关联.
- 确定特定的NAFLD患者子组,这些患者有更高的CRC风险.
主要方法:
- 利用了台湾国家健康保险研究数据库 (NHIRD) 的2000-2015年的数据.
- 包括52,986名患有NAFLD的患者,与使用倾向性得分匹配的对照组匹配.
- 使用考克斯回归和卡普兰-梅尔分析来确定CRC发病率,患者平均被跟踪了8.5年.
主要成果:
- 与对照组 (6.0/100,000人/年) 相比,NAFLD队列中的CRC发病率更高 (12.23/100,000人/年).
- NAFLD与CRC的调整后危险比率 (HR) 增加1.259 (95% CI: 1.047-1.486,P = .003).
- 在50岁以上的NAFLD患者中观察到CRC风险增加,特别是那些患有糖尿病 (DM) 和慢性肝病的人.
结论:
- NAFLD与结直肠癌的风险增加有显著的关联.
- 医生应该主动评估和管理NAFLD患者的CRC风险,特别是患有DM等并发症的老年人.
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