在分析显示PRR11是肺腺癌的预后和瘤标记物
Ankang Hu1, Kaicheng Tang2, Jing Liu3
1Laboratory Animal Center of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Medicine
|May 26, 2023
概括
富于的11 (PRR11) 在肺腺癌 (LUAD) 中过度表达,与预后不佳和免疫透改变有关. 对于LUAD患者来说,PRR11可能成为一种新的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 肺腺癌 (LUAD) 是一个重大的临床挑战,尽管有治疗方法,但患者的预后不佳.
- 确定新的治疗点和生物标志物对于改善LUAD结果至关重要.
- 普罗林丰富11 (PRR11) 在LUAD病原和预后中的作用需要进一步阐明.
研究的目的:
- 通过使用癌症基因组图谱 (TCGA) 数据库,研究PRR11在各种癌症中的表达模式.
- 为了评估PRR11在LUAD患者的预后意义.
- 探索PRR11与临床病理特征,免疫透和LUAD中相关分子通路的关联.
主要方法:
- 使用TCGA数据进行泛癌PRR11表达分析.
- 通过GEPIA通过LUAD对PRR11的预测价值评估2.
- 使用UALCAN对PRR11与临床病理特征的相关性分析.
- 研究PRR11与免疫细胞透的关系.
- 通过LinkOmics,GEPIA2和DAVID数据库识别与PRR11相关的基因和途径丰富分析 (GO,KEGG).
主要成果:
- 与正常组织相比,PRR11表达在大多数瘤组织中显著升高.
- 在LUAD中高PRR11表达与较短的整体存活率,首次进展存活率和后进展存活率相关.
- PRR11水平与LUAD阶段,种族,性别,吸烟状况和亚型有关.
- 升高的PRR11与癌症相关纤维细胞 (CAF) 和髓质衍生抑制细胞 (MDSC) 的透增加以及CD8+ T细胞透减少有关.
- 功能丰富分析表明PRR11参与细胞分裂,细胞循环,蛋白质结合,微管结合和p53信号通路.
结论:
- PRR11在LUAD中受到上调,并作为潜在的独立预后生物标志物.
- PRR11与免疫透的关联表明它在塑造瘤微环境中的作用.
- 在LUAD中,PRR11代表了开发新型治疗策略的有前途的治疗目标.
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