来自Porphyra haitanensis的氨酸增强了肠道屏障功能,调节了肠道微生物群的组成
Sathuvan Malairaj1,2, Suresh Veeraperumal1, Wanzi Yao2,3
1Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Provincial Science and Technology Innovation Center for Subtropical Fruit and Vegetable Processing, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Marine drugs
|May 26, 2023
概括
来自Porphyra haitanensis (PHP) 的粉素通过改善肠道屏障功能和促进有益的肠道细菌来增强肠道健康. 这种海藻提取物在食品和药品中显示出作为益生菌的潜力.
科学领域:
- 海洋生物技术 海洋生物技术
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 肠道屏障对健康至关重要,其功能障碍与各种疾病有关.
- 肠道微生物群在维持肠道平衡中起着至关重要的作用.
- 海藻衍生的多糖因其健康益处越来越受认可.
研究的目的:
- 为了研究来自Porphyra haitanensis (PHP) 的酸盐对小鼠肠道屏障功能和肠道微生物群组成的影响.
- 为了评估PHP作为一种前生物成分的潜力.
主要方法:
- 通过口服给小鼠使用PHP.
- 分析肠道光道环境 (pH,水分).
- 短链脂肪酸 (SCFA) 的测量.
- 肠道粘膜的组织学检查 (上皮细胞排列,杯状细胞,粘膜表达).
- 评估紧结蛋白表达 (ZO-1,奥克卢丁).
- 用于肠道微生物群分析的16S rRNA测序.
主要成果:
- PHP增加了结肠的光水分,降低了pH值,有利于有益的细菌.
- 在SCFA的总产量显著增加.
- 改善了肠道上皮细胞结构,增加了粘膜厚度,增强了粘素的产生.
- 紧结蛋白 (ZO-1,ocludin) 的高调表达,加强肠道屏障.
- 增加了肠道微生物群的丰富性,多样性和Firmicutes/Bacteroidetes比率.
结论:
- 通过增强结构完整性和粘素生产,PHP显著改善肠道屏障功能.
- PHP积极调节肠道微生物群的组成,增加有益的细菌和SCFA.
- 来自 Porphyra haitanensis 的 Porphyran 是功能性食品和制药品的有希望的益生菌候选者.
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