乳托费林用于经过胃肠道手术后的新生儿的术后治疗
Amit Trivedi1, Rajesh Maheshwari2, William O Tarnow-Mordi3
1Grace Centre for Newborn Care, The Children's Hospital at Westmead, Westmead, Australia.
The Cochrane database of systematic reviews
|May 26, 2023
概括
目前没有研究表明乳酸是否在胃肠道手术后对新生儿有益. 需要更多的随机对照试验来确定乳酸铁素.
科学领域:
- 新生儿手术 新生儿手术
- 胃肠道手术 胃肠道手术
- 传染性并发症 感染性并发症
背景情况:
- 接受胃肠道手术的新生儿面临由于肠道屏障破坏和改变的微生物群的后术感染的高风险.
- 乳酪蛋白中的乳酸蛋白具有抗微生物和抗炎性质,可能有助于肠道健康和免疫力.
- 之前的研究表明,乳酸铁素可能会减少早产婴儿的败血症,这表明它可能在术后新生儿中发挥作用.
研究的目的:
- 为了评估乳二在减轻术后新生儿的败血症和死亡率方面的疗效,胃肠道手术.
- 评估乳费林对肠道养,肠道菌群,住院和出院前死亡率的影响.
主要方法:
- 计划对随机对照试验 (RCT) 进行系统审查.
- 搜索包括主要数据库到2023年2月,没有语言或出版限制.
- 纳入标准是指在出生后28天内经过胃肠道手术的满期新生儿 (妊娠≥37周),将乳酸铁素与安慰剂进行比较.
主要成果:
- 没有发现符合纳入标准的已发表的随机对照试验.
- 在这个特定的患者群体中,乳酸铁素的疗效仍然没有被RCT评估.
结论:
- 目前,从RCT中没有证据支持或反驳在胃肠道手术后在新生儿中使用乳酸铁素.
- 进一步进行高质量的随机对照试验至关重要,以确定乳酸铁素在这个脆弱群体中的作用和安全性.
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