孕产妇的矿物营养调节了牛的胎儿基因组编程:一篇评论
Muhammad Anas1, Wellison J S Diniz2, Ana Clara B Menezes3
1Department of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 36849, USA.
Metabolites
|May 26, 2023
概括
孕产妇的矿物营养影响胎儿发育和牛的终身生产力. 这篇评论探讨了矿物质如何调节胎儿表观基因组,影响器官发育和代谢健康.
科学领域:
- 生殖生物学 生殖生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 动物科学动物科学
背景情况:
- 孕产妇的营养显著影响后代的健康和生产力,这是健康和疾病发育起源 (DOHaD) 的核心概念.
- 虽然宏观营养素已经得到了广泛的研究,但微量营养素,特别是矿物质在胎儿编程中的作用在牲畜,特别是牛群中仍未得到充分研究.
- 了解矿物驱动的表观遗传调节对于优化牲畜发展和生产率至关重要.
研究的目的:
- 审查母亲饮食矿物质对牛胎儿发育规划的影响,从胚胎到产后阶段.
- 阐明矿物质在调节胎儿表观基因组中的作用及其与器官发育的联系.
- 要突出由母体矿物供应和牛的表观基因交叉影响的关键调节途径.
主要方法:
- 文献综述综合牛研究,模型动物,细胞系和其他牲畜物种的发现.
- 对矿物质对基因调节和妊娠期间表观遗传修饰的影响现有数据的分析.
- 进行比较的方法来绘制不同物种和实验模型之间的平行线.
主要成果:
- 孕产妇的矿物质在胎儿-孕产妇基因组调节中起着协调作用,对于怀孕的建立和器官生成至关重要.
- 特定的矿物质影响重要胎儿组织的发育和功能,包括肝脏,骨肌肉和胎盘.
- 饮食中的矿物质供应与表观遗传学机制相互作用,以编程胎儿发育.
结论:
- 孕产妇的矿物营养是胎儿编程和牛长期生产力的关键决定因素.
- 矿物质是胎儿表观基因组的关键调节者,影响重要器官和组织的发育.
- 对矿物-表观基因组相互作用的进一步研究可以为改善牲畜健康和表现的策略提供信息.
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