维生素D不足对甲状腺荷尔蒙和腹手术后炎症标记物的影响
Roberta França1,2, Adryana Cordeiro2, Silvia Elaine Pereira2,3
1Faculty of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-598, Brazil.
Metabolites
|May 26, 2023
概括
适当的维生素D水平可以改善甲状腺激素,减少炎症,并在Roux-en-Y胃绕道手术 (RYGB) 后增强减肥. 维持足够的维生素D对于RYGB后更好的患者结果至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 腹部外科 腹部外科
- 营养科学 营养科学
背景情况:
- 维生素D的状态显著影响了经过Roux-en-Y胃绕道 (RYGB) 的患者的术后结果.
- 了解维生素D在调节RYGB后生理参数中的作用,对于优化患者护理至关重要.
研究的目的:
- 为了研究足够的维生素D血清度对甲状腺激素,体重,血细胞计数和RYGB之后的炎症的影响.
- 评估维生素D营养状况与RYGB后6个月和12个月的关键临床结果之间的相关性.
主要方法:
- 一项前性观察性研究,涉及88名接受RYGB.治疗的患者.
- 手术前和手术后6个月收集的血液样本,以测量25-氧维生素D (25(OH) D),甲状腺激素和血细胞计数.
- 在手术后6个月和12个月评估了体重,体重指数 (BMI),总体重减轻和过重体重减轻.
主要成果:
- 58%的患者在RYGB.后6个月内达到充足的维生素D状态.
- 适当的维生素D组表现出甲状腺刺激激素 (TSH) 水平显著下降 (p=0.017) 和较低的TSH度比不充分的组在6个月 (p=0.020).
- 在手术后12个月,具有充足维生素D状态的患者的BMI显著降低,与缺乏维生素D状态的患者相比 (p=0.018).
结论:
- 充足的维生素D营养状况与RYGB.之后改善的甲状腺激素水平有关.
- 足够的维生素D水平似乎会对免疫炎症概况产生积极影响,并增强RYGB后减肥的有效性.
- 保持最佳的维生素D状况是RYGB患者推的,以支持更好的临床和身体结果.
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