在塞尔维亚患者中,通过H-NMR对双极性障碍的代谢分析

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Updated: Jul 29, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

Katarina Simić¹, Zoran Miladinović², Nina Todorović¹

¹Institute of Chemistry, Technology and Metallurgy, National Institute, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.

|May 26, 2023

概括

这项研究在塞尔维亚患者中使用NMR代谢剂确定了双相情感障碍 (BD) 的新型血清生物标志物. 这些发现有助于为这种复杂的大脑疾病开发客观的诊断工具.

科学领域:

生物化学生物化学
神经科学是一个神经科学.
代谢学代谢学代谢学

背景情况:

双极性障碍 (BD) 是一种普遍存在的大脑障碍,影响情绪,能量和功能,全球有6000万人的负担.
复杂的病因包括遗传,环境和生化因素,再加上主观的基于症状的诊断,阻碍了对BD的理解和准确诊断.
当前的诊断挑战需要确定客观的生物标志物,以改善临床管理.

研究的目的:

通过基于H-NMR的代谢方法识别双相情感障碍 (BD) 的新型血清生物标志物.
在塞尔维亚患者队列中建立BD诊断的潜在生物标志物集.
将已识别的生物标志物与其他种族和地理群体中发现的生物标志物进行比较.

主要方法:

利用基于H-NMR的代谢量和化学测量对来自塞尔维亚BD患者和健康对照者的血清样本.
分析了33名BD患者和39名健康对照的血清样本.
在血清样本中识别和定量特定代谢物.

主要成果:

在塞尔维亚队列中确定了一组与双相情感障碍相关的22种代谢物.
为BD血清样本建立了一个新的生物标志物集,包括氨酸,酸,胺黄油酸,2-氧黄油酸,血清和曼诺酸.
在巴西和中国的BD患者样本中发现与之前识别的NMR基血清生物标志物对六种代谢物的一致性.

结论:

该研究成功地使用NMR代谢组学识别了一组新的双相情感障碍血清生物标志物.
已识别的代谢物显示出开发BD的客观诊断工具的潜力.
跨不同种族和地理来源的已识别代谢物的重叠表明,可能有一个基于NMR的普遍生物标志物用于BD.

关键词:

这是NMR的NMR.生物标志物生物标志物双相情感障碍是双相情感障碍的一种疾病.化学测量方法化学测量方法代谢生物组的代谢生物组血清代谢物的血清代谢物

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