重复的低水平爆炸暴露会改变尿液和血清代谢物
Austin Sigler1, Jiandong Wu1, Annalise Pfaff1
1Department of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, USA.
Metabolites
|May 26, 2023
概括
重复的低水平爆炸暴露会改变尿液和血清中的小分子代谢物,可能识别有轻度创伤性脑损伤 (TBI) 风险的个体. 需要进一步的研究来证实这些发现.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 军事医学 军事医学
背景情况:
- 重复的低级爆炸超压可以导致类似于轻度创伤性脑损伤 (TBI) 的生物变化.
- 对于轴突损伤的现有蛋白质生物标志物存在,但对于爆炸引起的大脑损伤的小分子生物标志物需要进一步研究.
研究的目的:
- 探索尿液和血清中潜在的小分子生物标志物,这些生物标志物表明重复低水平爆炸暴露导致的脑损伤.
- 分析参与神经传递,氧化应激和能量代谢的代谢物.
主要方法:
- 在军事人员 (n=27) 中评估了十种小分子代谢物,这些人正在接受反复暴露于爆炸的突破者训练.
- 使用HPLC-tandem质谱分析尿液和血清样本.
- 利用威尔科克森的签名等级测试来统计比较爆发前和爆发后的代谢物水平.
主要成果:
- 观察到尿中同酸 (p < 0.0001),酸 (p = 0.0030) 和谷氨酸 (p = 0.0027) 的显著变化.
- 观察到血清N-乙酸的显著变化 (p = 0.0006).
- 同酸水平显示,随着重复的爆炸暴露,其持续下降.
结论:
- 重复的低水平爆炸暴露会导致特定尿液和血清代谢物的可测量变化.
- 这些代谢物变化可能有助于识别患TBI风险较高的个体.
- 需要进行更大规模的临床研究来验证和概括这些发现.
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