益生菌治疗对患有后传染性疲劳的患者的积极影响
Katharina Obermoser1, Natascha Brigo1, Andrea Schroll1
1Department of Internal Medicine II, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Metabolites
|May 26, 2023
概括
这项研究发现,多菌株益生菌显著改善了比安慰剂更容易患有感染后疲劳的患者的疲劳,抑郁和生活质量. 益生菌对肠-大脑轴健康有前途.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 感染后疲劳会影响身体效率,情绪和生活质量.
- 肠道微生物群失调和肠-大脑轴与疲劳和心理健康有关.
- 研究针对感染后疲劳的干预措施至关重要.
研究的目的:
- 评估多菌株益生菌制剂在患有感染后疲劳的患者中的疗效.
- 评估益生菌对疲劳严重程度,抑郁和生活质量的影响.
- 探索涉及肠-大脑轴的潜在机制.
主要方法:
- 这是一项双盲,安慰剂控制的试点研究,涉及70名患者.
- 患者接受了多菌株益生菌或安慰剂6个月.
- 评估包括疲劳 (FSS),抑郁 (BDI-II),生活质量 (SF-36) 和生化标志物.
主要成果:
- 益生菌和安慰剂组都显示出改善,但益生菌在疲劳 (FSS) 和抑郁症 (BDI-II) 评分中显著降低.
- 益生菌干预导致了显著的整体生活质量改善,而安慰剂只改善了特定的子类别.
- 生物化学分析显示,在6个月后,安慰剂组的内波特林增加,干扰素-马通路没有显著变化.
结论:
- 多菌株益生菌代表了对后感染性疲劳的有希望的干预措施.
- 益生菌可以通过调节肠-大脑轴来改善疲劳,情绪和生活质量.
- 需要进一步的研究来阐明益生菌在感染后疲劳中的作用机制.
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