肠道微生物群与口服药物的相互作用及其对推进精准医学的影响
Sara Mousa1, Muhammad Sarfraz1, Walaa K Mousa1,2
1College of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 112612, United Arab Emirates.
Metabolites
|May 26, 2023
概括
肠道微生物组显著影响药物代谢和疗效,影响治疗结果. 了解这些微生物相互作用是开发个性化药物和改善药物反应的关键.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 基因组学就是基因组学.
背景情况:
- 人的肠道拥有数万亿种微生物,这些微生物对生理过程至关重要,包括药物代谢.
- 微生物药物代谢深深影响药物吸收,有效性和毒性,扩展到肝脏反应之外.
- 关于特定的肠道微生物菌株及其代谢酶的知识有限,尽管微生物群的酶能力巨大.
研究的目的:
- 审查宿主,口服药物和肠道微生物群之间的复杂,多方向相互作用.
- 分析有关肠道微生物和药物代谢的个性化医学当前的差距,挑战和未来的潜力.
- 突出肠道微生物在药物疗效和毒性方面的作用,影响治疗结果.
主要方法:
- 关于传统和机器学习方法的文献综述.
- 分析微生物药物代谢途径及其对药物反应的影响.
- 检查药物如何影响肠道微生物的组成和功能.
主要成果:
- 肠道微生物具有广泛的酶能力,可以显著改变药物代谢和药理作用.
- 微生物药物代谢可能导致药物反应变化,包括对化学疗法药物如凝胺的耐药性.
- 药物可以调节肠道微生物群落,使药物微生物群相互作用的预测变得复杂.
结论:
- 将肠道微生物群纳入药物代谢的理解对于个性化医学至关重要.
- 未来的治疗策略必须考虑宿主-微生物群-药物轴,以提高治疗疗效和降低毒性.
- 包括肠道微生物在内的个性化医疗方法承诺优化治疗方案和精确治疗.
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