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在患有双相情绪障碍和扰乱性情绪失调障碍的青少年中,食欲激素失调和执行功能障碍
Ju-Wei Hsu1,2, Li-Chi Chen1,2,3, Kai-Lin Huang1,2
1Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
European child & adolescent psychiatry
|May 26, 2023
概括
患有扰乱性情绪失调障碍 (DMDD) 的青少年表现出食欲激素失衡和更差的执行功能,与更高的胰岛素水平有关. 这表明代谢变化和青年的情绪障碍之间存在联系.
科学领域:
- 神经内分泌学神经内分泌学
- 儿童和青少年精神病学 儿童和青少年精神病学
- 代谢精神病学 代谢精神病学
背景情况:
- 胃口激素失调与双相情感障碍和慢性易怒性有关.
- 在患有双相情绪障碍和扰乱性情绪失调障碍 (DMDD) 的青少年中,食欲激素与执行功能障碍之间的联系尚不清楚.
研究的目的:
- 研究与健康对照组相比,双相情感障碍和DMDD青少年的食欲激素水平和执行功能之间的关联.
- 探索特定的食欲激素和执行功能障碍指标之间的潜在相关性.
主要方法:
- 横截面研究涉及20名患有双相情感障碍的青少年,20名患有DMDD的青少年和47名健康对照.
- 测量乳素, ghrelin,胰岛素和adiponectin的禁食血清水平.
- 使用威斯康星卡片排序测试对执行职能进行评估.
主要成果:
- 与对照组相比,患有DMDD的青少年表现出明显更高的禁食胰岛素水平.
- 患有DMDD的患者在威斯康星州卡片排序测试中表现较差 (第一类的试验更多).
- 双极性障碍患者在测试中完成了较少的类别.
- 胰岛素水平升高与DMDD患者第一个类别所需的试验增加正相关.
结论:
- 患有DMDD的青少年,与患有双相情感障碍的青少年不同,表现出胃口激素失调.
- 在DMDD患者中,胰岛素水平升高与执行功能障碍有关.
- 需要进一步的研究来澄清食欲激素失调,执行功能障碍和情绪失调之间的时间关系.
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