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神经纤维光链和心脏MIBG吸收作为REM睡眠行为障碍中异常变异的预测因子

Don Gueu Park¹, Ju Yeong Kim², Min Seung Kim³

¹Department of Neurology, Ajou University School of Medicine, 164, Worldcup-Ro, Songjae Hall, Suwon-Si, Gyeonggi-Do, 16499, South Korea.

Journal of neurology

|May 26, 2023

概括

血神经纤维光链 (NfL) 和心脏metaliodobenzylguanidine (MIBG) 的吸收可以预测孤立的快速眼动睡眠行为障碍 (iRBD) 患者是否会发展多个系统缩 (MSA) 或勒维体病 (LBD).

科学领域:

神经学神经学
睡眠医学睡眠医学
生物标志物发现发现

背景情况:

孤立的快速眼动睡眠行为障碍 (iRBD) 是神经退行性疾病的前兆阶段,如多系统缩 (MSA) 和莱维体病 (LBD).
在iRBD患者中预测和区分未来的表态转化仍然是一个挑战.
作为预测生物标志物,研究血神经丝光链 (NfL) 和心脏金属基胺 (MIBG) 的吸收是至关重要的.

研究的目的:

评估血NfL和心脏MIBG吸收对于iRBD患者的转换的预测值.
根据这些生物标志物,区分未来的MSA和LBD发展.
建立用于早期神经退行性疾病预测的潜在诊断工具.

主要方法:

对40名iRBD患者的前性随访,平均时间为2.92年.
在基线测量血NfL水平.
在基线对心脏MIBG吸收和条状多巴胺载体吸收的评估.

主要成果:

血NfL水平升高 (21.3 pg/mL以上) 准确预测了MSA的表转化 (100%的灵敏度,94.3%的特异性).
低心脏MIBG吸收 (低于1.545心脏与中枢的比率) 准确地预测了转化为LBD的现象 (100%的灵敏度,92.9%的特异性).
血NfL在未来的MSA转换器中明显高于其他转换器.

结论:

血NfL和心脏MIBG吸收作为有价值的生物标志物用于预测iRBD中的转化.
血NfL升高表明即将转化为MSA.
心脏MIBG摄入量减少表明可能转化为LBD.

关键词:

多重系统缩多重系统缩神经纤维光电链的链条帕金森病是帕金森氏症的一种疾病.雷姆睡眠行为障碍雷姆睡眠行为障碍

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