布克小麦基乳液凝的特征,形成机制和黄的递送方法
Xiaoyu Yin1, Rumeng Yu1, Junping Zhang1
1College of Biological Sciences and Technology, Beijing Key Laboratory of Food Processing and Safety in Forestry, Beijing Forestry University, Beijing 100083, China.
Journal of agricultural and food chemistry
|May 26, 2023
概括
研究人员从麦蛋白质中制造出一种基于天然的乳液凝. 这种新的凝提供了增强的稳定性和可控释放的化合物,如黄素.
科学领域:
- 食品科学 食品科学 食品科学
- 生物材料是一种生物材料.
- 蛋白质化学 蛋白质化学
背景情况:
- 传统的基于蛋白质的凝在加工条件下往往缺乏稳定性.
- 从自然来源开发新的输送系统对于食品和制药应用至关重要.
研究的目的:
- 从麦蛋白质构建一个稳定的基于的乳液凝 (PG).
- 描述PG的结构性,学性和稳定性特性.
- 为了研究凝机制和黄素释放行为.
主要方法:
- 麦蛋白质的温和酶性水解以获得小.
- 形成基于的乳液凝 (PG).
- 对PG纹理,粘性弹性,热和冷-解稳定的分析.
- 使用各种分析技术研究-油相互作用.
- 在体外肠道消化和黄素释放研究.
主要成果:
- 一个多孔的,紧密的质感PG与固体凝粘弹性成功构建.
- 与原始蛋白质凝相比,PG对加热和冷解具有优越的抗性.
- 疏水聚合,H结合和排斥力有助于凝矩阵增强.
- 该PG证明了黄素的pH响应性嵌入和释放,达到53.9%的释放率.
结论:
- 基于天然的乳液凝为传统基于蛋白质的系统提供了一个有前途的替代方案.
- 开发的PG表现出卓越的稳定性和可控释放能力.
- 这种天然的PG在食品和药物输送系统中具有潜在的应用.
相关概念视频
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Bioavailability Enhancement: Drug Permeability Enhancement
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...


