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Updated: Jul 29, 2025

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患者报告的结果作为非小细胞肺癌反应的放射间预测结果

Ambika S Bhatt^1,2, Matthew B Schabath³, Aasha I Hoogland⁴

¹Department of Biostatistics, Gillings School of Global Public Health at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Clinical cancer research : an official journal of the American Association for Cancer Research

|May 26, 2023

概括

患者报告的结果 (PROs) 可以预测癌症的进展. 失眠等症状的动态变化准确地预测了接受免疫治疗的肺癌患者的瘤体积变化.

科学领域:

在瘤学瘤学.
生物标志物生物标志物
患者报告的结果

背景情况:

微创生物标志物对于跟踪癌症治疗反应和进展至关重要.
患者报告结果 (PROs) 提供了个性化的,非侵入性的生活质量和症状衡量标准,越来越多地融入常规护理.
现有的研究将特定的PRO与生存联系起来,但往往忽视了动态的,患者特定的变化.

研究的目的:

研究PRO动态的预测能力,作为瘤体积变化的放射间指标.
确定能够准确预测接受免疫治疗的非小细胞肺癌 (NSCLC) 患者治疗反应的特定PRO.

主要方法:

在接受免疫治疗的85名NSCLC患者中分析了PRO动态.
每两周收集PRO问卷,每月进行瘤体积扫描.
利用相关性和预测分析来识别重要的PRO预测因素.

主要成果:

瘤体积的变化与头,失眠和疲劳有显著的相关性.
失眠的累积变化预测了疾病的进展,准确率为77%,平均在成像之前45天.
PRO动态提供了对治疗反应和疾病进展的早期见解.

结论:

这项研究开创了使用患者特定的PRO动态来预测个体治疗反应的先驱.
考虑到动态的PRO变化是定制癌症治疗和改善结果的关键进步.
PRO动态代表了个性化癌症护理的一个有希望的新方法.

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