在2型糖尿病患者和健康对照者中通过安慰剂影响胰岛素系统:一项随机对照试验
Aleksandrina Skvortsova1, Dieuwke S Veldhuijzen, Lotte F van Dillen
1From the Department of Psychology (Skvortsova), McGill University, Montreal, Quebec, Canada; Health, Medical and Neuropsychology Unit (Skvortsova, Veldhuijzen, Zech, Derksen, Sars, Evers), and Social, Economic and Organizational Psychology Unit (van Dillen), Faculty of Social and Behavioural Sciences, Leiden University, Leiden, the Netherlands; Neuroimaging Center (Zech), Dresden University of Technology, Dresden, Germany; Department of Medicine, Division of Endocrinology (Meijer, Pijl), Leiden University Medical Centre; Department of Psychiatry (Evers), Leiden University Medical Center, Leiden; and Medical Delta, Leiden University (Evers), Technical University Delft and Erasmus University, Delft, the Netherlands.
用鼻内胰岛素进行药理调节可以减少健康成年人的饥饿感,并稳定2型糖尿病男性的葡萄糖水平. 这种安慰剂效应显示出控制饥饿的潜力,但对降低血糖效果不那么有效.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
背景情况:
- 假药效应,特别是当它是由药理学条件所诱导时,是一种复杂的现象.
- 鼻内胰岛素在调节各种生理和认知功能方面表现出潜力.
研究的目的:
- 为了研究安慰剂效应的影响,由药理学调节与鼻内胰岛素诱导,对葡萄糖,胰岛素,C-,饥饿和记忆.
- 为了比较老年人2型糖尿病和健康对照者的这些影响.
主要方法:
- 药理学调节使用鼻内胰岛素和树油气味作为条件刺激.
- 随机对照试验包括32名2型糖尿病患者和32名健康对照.
- 重复测量血糖,胰岛素和C-的血量,以及对饥饿和记忆的验证评估.
主要成果:
- 鼻内胰岛素稳定了2型糖尿病患者和健康男性的葡萄糖水平.
- 通过鼻内胰岛素进行调节,可以防止男性的葡萄糖下降,并显著减少健康参与者的饥饿感.
- 在健康对照组中观察到C-水平的下降.
结论:
- 胰岛素调节的安慰剂效应会影响血糖和饥饿感,影响因健康状况和性别而异.
- 胰岛素调节可能有利于经历严重饥饿的人.
- 这项研究表明,这种调节方法在降低血糖的有效性有限.
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