相关实验视频

Updated: Jul 29, 2025

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

一个细胞跨膜化物M(27-39) -HTPP针对肝细胞癌的向治疗

Jibin Wu¹, Rui Deng¹, Jianling Yan¹

¹Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, 280 Wai Huan Dong Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, People's Republic of China.

|May 26, 2023

概括

一种新型的,M27-39) -HTPP,有效地向并透肝细胞癌 (HCC) 瘤. 这种可以抑制癌细胞的生长和扩散,为HCC提供安全有效的新疗法.

科学领域:

在瘤学瘤学.
类治疗药物类治疗药物
生物技术是生物技术.

背景情况:

肝细胞癌 (HCC) 是一个主要的全球健康问题,发病率和死亡率不断增加.
目前的HCC治疗策略在瘤向,透和抑制癌细胞增殖,迁移和入侵方面面临挑战.

研究的目的:

开发和评估一种新的联,M(27-39) -HTPP,用于向的HCC治疗.
评估M(27-39) -HTPP在抑制HCC进展和诱导亡方面的疗效.
为了确定M(27-39) -HTPP在治疗剂量中的生物安全性.

主要方法:

合成M27-39) -HTPP通过将M27-39与HTPP向肝脏的合.
在体外和体内评估M(27-39) -HTPP的瘤向和透能力.
评估M(27-39) -HTPP对HCC细胞增殖,迁移,入侵和亡的影响.
在治疗环境中对M(27-39)-HTPP的生物安全性评估.

主要成果:

在HCC模型中,M(27-39)-HTPP表现出显著的瘤向和透能力.
联有效地抑制了HCC细胞的增殖,迁移和入侵.
M(27-39) -HTPP在HCC细胞中成功诱导了亡.
治疗性在有效剂量下表现出良好的生物安全性.

结论:

M(27-39) -HTPP是一种有前途的新型治疗,用于肝细胞癌.
结合剂提供了一种安全有效的方法来准和治疗HCC.
进一步开发M(27-39) -HTPP可能会改善HCC患者的临床结果.

关键词:

癌症癌症癌症癌症化学化学化学在瘤学瘤学.

更多相关视频

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Translocation of Proteins into the Mitochondria

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...